An algorithm for managing warfarin resistance (2014); Free in PubMed

10 Oct 2014
2009 Dec;76(12):724-30. doi: 10.3949/ccjm.76a.09062.

An algorithm for managing warfarin resistance.


Some patients need higher-than-expected doses of warfarin (Coumadin) to get their international normalized ratio (INR) into the therapeutic range. The cause of warfarin resistance can be either acquired (eg, poor compliance, drug interactions, dietary interactions) or hereditary, but the genetic mechanisms of warfarin resistance are not well understood. This review offers an algorithm for the evaluation of patients with suspected warfarin resistance.

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