About Us

Summary

Calciphylaxis (or calcific uraemic arteriolopathy) is a syndrome of medial calcification of small arteries leading to painful ischaemia, usually of the skin, almost exclusively found in patients with CKD. Mortality in reported case series is 60-80% with no effective treatment known. The pathophysiology remains poorly understood but recent advances in vascular biology have demonstrated that vascular calcification is a highly regulated process.

If this process can be comprehensively examined through phenotypic, genotypic and proteomic analysis the opportunity to identify therapeutic targets, either within the current therapeutic armamentarium or with newer agents, and design intervention studies for calciphylaxis may become feasible.

Given this condition is uncommon, a national calciphylaxis registry is the only means to collect and collate data prospectively to improve clinical management and outcomes for patients with this disorder.